Structure of PDB 7wq3 Chain R

Receptor sequence
>7wq3R (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
ENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIAD
LAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSV
DRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRA
SNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKL
KNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPAS
FLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKC
3D structure
PDB7wq3 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
ChainR
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R E32 V95 H112 F186 W188 Q190 F275 L277 F282 R285 E1 V64 H81 F155 W157 Q159 F244 L246 F251 R254
BS02 CLR R A128 V131 R147 N151 A97 V100 R116 N120
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004966 galanin receptor activity
GO:0005515 protein binding
GO:0008528 G protein-coupled peptide receptor activity
GO:0017046 peptide hormone binding
GO:0042923 neuropeptide binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051464 positive regulation of cortisol secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wq3, PDBe:7wq3, PDBj:7wq3
PDBsum7wq3
PubMed
UniProtP47211|GALR1_HUMAN Galanin receptor type 1 (Gene Name=GALR1)

[Back to BioLiP]