Structure of PDB 7vv5 Chain R

Receptor sequence
>7vv5R (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
LLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSL
AGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLS
TVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFL
FSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRL
YLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLN
SSANPIIYFFVGSFRKQW
3D structure
PDB7vv5 Structure, function and pharmacology of human itch receptor complexes.
ChainR
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR R V66 W154 V45 W133
BS02 6IB R L22 S177 D184 W243 W248 S253 L1 S156 D163 W222 W227 S232
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0042923 neuropeptide binding
GO:1990595 mast cell secretagogue receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0019233 sensory perception of pain
GO:0030431 sleep
GO:0032467 positive regulation of cytokinesis
GO:0043303 mast cell degranulation
GO:0045576 mast cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7vv5, PDBe:7vv5, PDBj:7vv5
PDBsum7vv5
PubMed34789875
UniProtQ96LB1|MRGX2_HUMAN Mas-related G-protein coupled receptor member X2 (Gene Name=MRGPRX2)

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