Structure of PDB 7vv4 Chain R

Receptor sequence
>7vv4R (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
GKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADF
LFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTE
RCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGD
SGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTIL
LTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANP
IIYFFVGSFRKQW
3D structure
PDB7vv4 Structure, function and pharmacology of human itch receptor complexes.
ChainR
Resolution2.97 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R M109 C168 G169 F170 S177 D184 W243 F257 H261 M83 C142 G143 F144 S151 D158 W217 F231 H235
BS02 CLR R C150 W154 C124 W128
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0042923 neuropeptide binding
GO:1990595 mast cell secretagogue receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0019233 sensory perception of pain
GO:0030431 sleep
GO:0032467 positive regulation of cytokinesis
GO:0043303 mast cell degranulation
GO:0045576 mast cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vv4, PDBe:7vv4, PDBj:7vv4
PDBsum7vv4
PubMed34789875
UniProtQ96LB1|MRGX2_HUMAN Mas-related G-protein coupled receptor member X2 (Gene Name=MRGPRX2)

[Back to BioLiP]