Structure of PDB 7vdm Chain R

Receptor sequence
>7vdmR (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
IPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCF
QIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSV
LWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQ
TFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLV
FLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFF
VGS
3D structure
PDB7vdm Structure, function and pharmacology of human itch receptor complexes.
ChainR
Resolution2.98 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R C168 F170 C180 W243 L247 C137 F139 C149 W212 L216
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0042923 neuropeptide binding
GO:1990595 mast cell secretagogue receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0019233 sensory perception of pain
GO:0030431 sleep
GO:0032467 positive regulation of cytokinesis
GO:0043303 mast cell degranulation
GO:0045576 mast cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vdm, PDBe:7vdm, PDBj:7vdm
PDBsum7vdm
PubMed34789875
UniProtQ96LB1|MRGX2_HUMAN Mas-related G-protein coupled receptor member X2 (Gene Name=MRGPRX2)

[Back to BioLiP]