Structure of PDB 7utz Chain R

Receptor sequence
>7utzR (length=600) Species: 9606 (Homo sapiens) [Search protein sequence]
GMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSH
AFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVN
AFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDA
FGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFL
HLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSETLQAFDSHYDYTIC
GDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILL
TSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQT
GPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA
IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLN
IVAFVIVCCCYVKIYITVRNDTKIAKRMAVLIFTDFICMAPISFYALSAI
LNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGI
3D structure
PDB7utz Autoantibody mimicry of hormone action at the thyrotropin receptor.
ChainR
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z41 R F405 L570 P571 M572 T574 A647 I648 I654 L663 Y667 F315 L480 P481 M482 T484 A549 I550 I556 L565 Y569
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0016500 protein-hormone receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7utz, PDBe:7utz, PDBj:7utz
PDBsum7utz
PubMed35940205
UniProtA0A0A0MTJ0

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