Structure of PDB 7uck Chain R

Receptor sequence

>7uckR (length=180) Species: 9986 (Oryctolagus cuniculus)

SMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLII
RKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRI
LRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKAR
KKLLADQAEARRSKTKEARKRREERLQAKK

3D structure

• PDB: 7uck Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
• Chain: R
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	R	M3 R5 K8 R9 R16 G18 K19 K20 K21 W23 L24 P26 R38 Q39 R42 K43 K46 T56 V57 H58 S59 R60 R62 R64 R70 R71 R74 H75 M76 G77 I78 G79 K80 R81 K82 G83 T84 N86 A87 R88 P90 E91 K92 V93 W95 M96 R100 R103 R110 K114 R117 H118 Y120 H121 Y124 K128 G129 N130 K135 H143	M2 R4 K7 R8 R15 G17 K18 K19 K20 W22 L23 P25 R37 Q38 R41 K42 K45 T55 V56 H57 S58 R59 R61 R63 R69 R70 R73 H74 M75 G76 I77 G78 K79 R80 K81 G82 T83 N85 A86 R87 P89 E90 K91 V92 W94 M95 R99 R102 R109 K113 R116 H117 Y119 H120 Y123 K127 G128 N129 K134 H142
BS02	rna	R	R162 R163 K165 T166 R170 R172 R176	R161 R162 K164 T165 R169 R171 R175

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7uck, PDBe:7uck, PDBj:7uck
• PDBsum: 7uck
• PubMed: 35679869
• UniProt: G1TYL6|RL19_RABIT Large ribosomal subunit protein eL19 (Gene Name=RPL19)