Structure of PDB 7trp Chain R

Receptor sequence
>7trpR (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIG
AFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYF
CVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVAARERK
VTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNST
INPACYALCNATFKKTF
3D structure
PDB7trp Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
ChainR
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IUE R Y89 Y92 F186 N423 D432 W435 Y57 Y60 F154 N226 D235 W238
BS02 IXO R D112 Y113 S116 N117 A203 W413 Y416 N417 Y439 D80 Y81 S84 N85 A171 W216 Y219 N220 Y242
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016907 G protein-coupled acetylcholine receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0040012 regulation of locomotion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7trp, PDBe:7trp, PDBj:7trp
PDBsum7trp
PubMed
UniProtP08173|ACM4_HUMAN Muscarinic acetylcholine receptor M4 (Gene Name=CHRM4)

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