Structure of PDB 7s8m Chain R

Receptor sequence
>7s8mR (length=253) Species: 562,9606 [Search protein sequence]
KETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFL
FLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTER
CLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDS
GWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILL
TVLVFLLCGLPFGIQWFLILWIWLFCHIHPVSVVLSSLNSSANPIIYFFV
GSF
3D structure
PDB7s8m Structure, function and pharmacology of human itch GPCRs.
ChainR
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R N85 C168 D184 W243 F257 N58 C141 D157 W216 F225
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0042923 neuropeptide binding
GO:0046872 metal ion binding
GO:1990595 mast cell secretagogue receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0019233 sensory perception of pain
GO:0022900 electron transport chain
GO:0030431 sleep
GO:0032467 positive regulation of cytokinesis
GO:0043303 mast cell degranulation
GO:0045576 mast cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Biological Process
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Cellular Component
External links
PDB RCSB:7s8m, PDBe:7s8m, PDBj:7s8m
PDBsum7s8m
PubMed34789874
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q96LB1|MRGX2_HUMAN Mas-related G-protein coupled receptor member X2 (Gene Name=MRGPRX2)

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