Structure of PDB 7rbt Chain R

Receptor sequence
>7rbtR (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
GQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNA
TARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFL
DQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFT
SFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVG
ANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVR
YLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTR
DYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSF
QGFLVSVLYCFINKEVQSEIRRGWHHCR
3D structure
PDB7rbt Structural determinants of dual incretin receptor agonism by tirzepatide.
ChainR
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 41Y R V347 H353 L380 F383 Q384 L387 V314 H320 L347 F350 Q351 L354
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005515 protein binding
GO:0008528 G protein-coupled peptide receptor activity
GO:0016519 gastric inhibitory peptide receptor activity
GO:0017046 peptide hormone binding
GO:0120022 glucagon family peptide binding
Biological Process
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0006091 generation of precursor metabolites and energy
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0031018 endocrine pancreas development
GO:0032024 positive regulation of insulin secretion
GO:0038192 gastric inhibitory peptide signaling pathway
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0048678 response to axon injury
GO:0050796 regulation of insulin secretion
GO:0051592 response to calcium ion
GO:0070542 response to fatty acid
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rbt, PDBe:7rbt, PDBj:7rbt
PDBsum7rbt
PubMed35333651
UniProtP48546|GIPR_HUMAN Gastric inhibitory polypeptide receptor (Gene Name=GIPR)

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