Structure of PDB 7oni Chain R

Receptor sequence

>7oniR (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]

KMFSLKKWNAVAMWSWDVECDTCAICRVQVMDACLRCQAENKQEDCVVVW
GECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK

3D structure

PDB

7oni CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.

Chain

Resolution

3.4 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	R	C50 H85 C88	C23 H58 C61
BS02	ZN	R	C61 C64 C73 C87	C34 C37 C46 C60
BS03	ZN	R	C80 H82 C99	C53 H55 C72

Gene Ontology

	Molecular Function
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0019788	NEDD8 transferase activity
GO:0046872	metal ion binding
GO:0061630	ubiquitin protein ligase activity
GO:0061663	NEDD8 ligase activity
GO:0097602	cullin family protein binding

	Biological Process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0038026	reelin-mediated signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687	post-translational protein modification
GO:0045116	protein neddylation
GO:0051775	response to redox state
GO:0070979	protein K11-linked ubiquitination
GO:2001222	regulation of neuron migration

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031466	Cul5-RING ubiquitin ligase complex

External links

PDB	RCSB:7oni, PDBe:7oni, PDBj:7oni
PDBsum	7oni
PubMed	34518685
UniProt	Q9UBF6\|RBX2_HUMAN RING-box protein 2 (Gene Name=RNF7)