Structure of PDB 7mby Chain R

Receptor sequence
>7mbyR (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
EWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSD
LMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISL
ERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTK
NNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELY
QLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPIS
FILLLSYTSSCVNPIIYCFMNKRFRLGFMATFP
3D structure
PDB7mby Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
ChainR
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R E38 N98 P101 K105 M121 V125 Y176 R197 R336 E344 S348 I352 L356 Y360 E1 N61 P64 K68 M84 V88 Y139 R160 R233 E241 S245 I249 L253 Y257
BS02 Y01 R R73 W166 R36 W129
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004951 cholecystokinin receptor activity
GO:0017046 peptide hormone binding
GO:0042277 peptide binding
Biological Process
GO:0001764 neuron migration
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0030900 forebrain development
GO:0032870 cellular response to hormone stimulus
GO:0038188 cholecystokinin signaling pathway
GO:0046883 regulation of hormone secretion
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7mby, PDBe:7mby, PDBj:7mby
PDBsum7mby
PubMed34086670
UniProtP32238|CCKAR_HUMAN Cholecystokinin receptor type A (Gene Name=CCKAR)

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