Structure of PDB 7m20 Chain R

Receptor sequence
>7m20R (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVY
YNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTL
LISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETY
CIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVK
VAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQDAT
3D structure
PDB7m20 Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action.
ChainR
Resolution3.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP R G10 Q11 C12 E69 G140 G142 T143 V169 N204 Y222 G10 Q11 C12 E69 G140 G142 T143 V169 N204 Y222
BS02 YNP R G98 N99 N100 T178 V179 F394 W397 G98 N99 N100 T178 V179 F394 W397
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:1990890 netrin receptor binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0007411 axon guidance
GO:0030182 neuron differentiation
GO:0038007 netrin-activated signaling pathway
GO:1990791 dorsal root ganglion development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0045171 intercellular bridge
GO:0070062 extracellular exosome
GO:0071944 cell periphery
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7m20, PDBe:7m20, PDBj:7m20
PDBsum7m20
PubMed34461087
UniProtQ13509|TBB3_HUMAN Tubulin beta-3 chain (Gene Name=TUBB3)

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