Structure of PDB 7f4d Chain R

Receptor sequence
>7f4dR (length=263) Species: 562,9606 [Search protein sequence]
LEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDL
LVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFL
GAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDH
VAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKLKGAVTLTI
LLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDP
LIYAFHSQELRRT
3D structure
PDB7f4d Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
ChainR
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R F45 E94 T95 Q114 D117 D121 T124 Y183 L189 L192 H260 L261 I264 P268 F280 F10 E59 T60 Q79 D82 D86 T89 Y148 L154 L157 H215 L216 I219 P223 F235
BS02 CA R E94 D117 D121 E59 D82 D86
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008528 G protein-coupled peptide receptor activity
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0031625 ubiquitin protein ligase binding
GO:0042562 hormone binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0009650 UV protection
GO:0019222 regulation of metabolic process
GO:0019233 sensory perception of pain
GO:0022900 electron transport chain
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035556 intracellular signal transduction
GO:0042438 melanin biosynthetic process
GO:0043473 pigmentation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060259 regulation of feeding behavior
GO:0070914 UV-damage excision repair
GO:0141163 positive regulation of cAMP/PKA signal transduction
GO:2000253 positive regulation of feeding behavior
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7f4d, PDBe:7f4d, PDBj:7f4d
PDBsum7f4d
PubMed34453129
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q01726

[Back to BioLiP]