Structure of PDB 7ew2 Chain R

Receptor sequence
>7ew2R (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLREHYQYVGKLAGRSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHN
RMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVAL
GASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALP
ILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLV
KSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQ
ACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRL
3D structure
PDB7ew2 Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes.
ChainR
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J89 R R31 N95 S99 T103 E115 M118 L122 R16 N73 S77 T81 E93 M96 L100 BindingDB: IC50=6.3nM,EC50=3.3nM,Ki=13nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0038036 sphingosine-1-phosphate receptor activity
Biological Process
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007219 Notch signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0019222 regulation of metabolic process
GO:0032651 regulation of interleukin-1 beta production
GO:1903141 negative regulation of establishment of endothelial barrier
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0098793 presynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ew2, PDBe:7ew2, PDBj:7ew2
PDBsum7ew2
PubMed34545189
UniProtQ99500|S1PR3_HUMAN Sphingosine 1-phosphate receptor 3 (Gene Name=S1PR3)

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