Structure of PDB 7dfl Chain R

Receptor sequence
>7dflR (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
MPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVG
AVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYR
SVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRRE
DKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCLHMNRE
RKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYIN
STLNPLIYPLCNENFKKTFKRILHI
3D structure
PDB7dfl Cryo-EM structure of the human histamine H 1 receptor/G q complex.
ChainR
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HSM R Y108 T112 N198 Y431 F432 Y81 T85 N171 Y221 F222 BindingDB: EC50=190nM,Ki=6000nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007613 memory
GO:0008542 visual learning
GO:0043114 regulation of vascular permeability
GO:0045907 positive regulation of vasoconstriction
GO:0048167 regulation of synaptic plasticity
GO:0071420 cellular response to histamine
GO:0098664 G protein-coupled serotonin receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dfl, PDBe:7dfl, PDBj:7dfl
PDBsum7dfl
PubMed33828102
UniProtP35367|HRH1_HUMAN Histamine H1 receptor (Gene Name=HRH1)

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