Structure of PDB 7cx2 Chain R

Receptor sequence
>7cx2R (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
ESPAISSVMFSAGVLGNLIALALLARSLFHVLVTELVFTDLLGTCLISPV
VLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSI
GHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCF
IRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRAEETDHLI
LLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWV
FAILRPPVLRLMRSVL
3D structure
PDB7cx2 Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
ChainR
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P2E R S28 T82 S86 Y93 T123 L298 R302 S305 N307 S6 T44 S48 Y55 T85 L234 R238 S241 N243 BindingDB: Ki=4.9nM,IC50=2.6nM,EC50=331nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004957 prostaglandin E receptor activity
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0009624 response to nematode
GO:0032496 response to lipopolysaccharide
GO:0032570 response to progesterone
GO:0042127 regulation of cell population proliferation
GO:0071380 cellular response to prostaglandin E stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:7cx2, PDBe:7cx2, PDBj:7cx2
PDBsum7cx2
PubMed33811074
UniProtP43116|PE2R2_HUMAN Prostaglandin E2 receptor EP2 subtype (Gene Name=PTGER2)

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