Structure of PDB 6xbj Chain R

Receptor sequence
>6xbjR (length=465) Species: 9606 (Homo sapiens) [Search protein sequence]
HCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGL
RNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERG
WPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEG
CGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRY
PAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETL
SCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHL
LTWSLPFVLTVAILAVAQVDGRSVSGICFVGYKNYRYRAGFVLAPIGLVL
IVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGF
VLITFSCHFYDFFNQAEWERSFRDYVLCQANVDCEIKNRPSLLVEKINLF
AMFGTGIAMSTWVWT
3D structure
PDB6xbj Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
ChainR
Resolution3.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR R L325 V329 Y394 V404 I408 H470 N521 M525 T528 L263 V267 Y332 V342 I346 H408 N448 M452 T455
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6xbj, PDBe:6xbj, PDBj:6xbj
PDBsum6xbj
PubMed32929279
UniProtQ99835|SMO_HUMAN Protein smoothened (Gene Name=SMO)

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