Structure of PDB 6wzg Chain R

Receptor sequence
>6wzgR (length=379) Species: 9606 (Homo sapiens) [Search protein sequence]
RLCDVLQVLWEEQDQCLQELSREQTGDLGTEQPVPGCEGMWDNISCWPSS
VPGRMVEVECPRFLRMLTSRNGSLFRNCTQDGWSETFPRPNLACGVNVND
SSNEKRHSYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHM
HLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAGCKLVMVLFQYCIMAN
YSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHF
LEDVGCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQET
RGNEVSHYKRLARSTLLLIPLFGIHYIVFAFSPEDAMEIQLFFELALGSF
QGLVVAVLYCFLNGEVQLEVQKKWQQWHL
3D structure
PDB6wzg Structure and dynamics of the active Gs-coupled human secretin receptor.
ChainR
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R R30 L31 V125 H136 L139 K143 Y146 Y150 N192 K195 F200 S202 D203 F222 Q223 I226 Y230 D287 I288 N289 I298 M366 L370 E373 L374 R1 L2 V96 H107 L110 K114 Y117 Y121 N163 K166 F171 S173 D174 F193 Q194 I197 Y201 D258 I259 N260 I269 M337 L341 E344 L345
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6wzg, PDBe:6wzg, PDBj:6wzg
PDBsum6wzg
PubMed32811827
UniProtP47872|SCTR_HUMAN Secretin receptor (Gene Name=SCTR)

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