Structure of PDB 6wm2 Chain R

Receptor sequence
>6wm2R (length=753) Species: 9606 (Homo sapiens) [Search protein sequence]
ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFV
NEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFE
KIENELKEINTNQEALKRNFLELTELKFILRKTGFVAGVINRERIPTFER
MLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKK
ICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQA
AAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQF
ALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGT
YREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKN
ENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMF
TYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSF
KMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGY
LVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGI
QCFLVVVALLCVPWMLLFKPLVLRRQYLRRKFDFGDTMVHQAIHTIEYCL
GCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFF
TAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFEH
IRE
3D structure
PDB6wm2 Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
ChainR
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA R F618 S619 F583 S584
BS02 BMA R S602 E603 S567 E568
BS03 MAN R Q501 L502 Q466 L467
BS04 CLR R F370 L452 F456 F335 L417 F421
BS05 WJP R K538 K593 L608 F616 K503 K558 L573 F581
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0051117 ATPase binding
Biological Process
GO:0007035 vacuolar acidification
GO:0007042 lysosomal lumen acidification
GO:0016241 regulation of macroautophagy
GO:0048388 endosomal lumen acidification
GO:0097401 synaptic vesicle lumen acidification
GO:1902600 proton transmembrane transport
Cellular Component
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0016607 nuclear speck
GO:0030665 clathrin-coated vesicle membrane
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0033176 proton-transporting V-type ATPase complex
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0101003 ficolin-1-rich granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wm2, PDBe:6wm2, PDBj:6wm2
PDBsum6wm2
PubMed33065002
UniProtQ93050|VPP1_HUMAN V-type proton ATPase 116 kDa subunit a 1 (Gene Name=ATP6V0A1)

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