Structure of PDB 6vms Chain R

Receptor sequence
>6vmsR (length=278) Species: 9606,10665 [Search protein sequence]
PHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADL
LVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISID
RYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNE
CIIANPAFVVYSSIVSFYVPFIVILLVYIKIYIVLRRRRKLVNTNRKLSQ
QKEKKATQLLAIYLGLFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLG
YVNSAINPIIYTTFNIEFRKAFLKILHC
3D structure
PDB6vms Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.
ChainR
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 08Y R D114 C118 T119 I183 I184 W386 F389 F390 T412 D83 C87 T88 I152 I153 W221 F224 F225 T247
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Cellular Component
External links
PDB RCSB:6vms, PDBe:6vms, PDBj:6vms
PDBsum6vms
PubMed32528175
UniProtD9IEF7;
P14416|DRD2_HUMAN D(2) dopamine receptor (Gene Name=DRD2)

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