Structure of PDB 6p02 Chain R

Receptor sequence

>6p02R (length=91) Species: 83332 (Mycobacterium tuberculosis H37Rv)

cVTIDADLMDAADLLEGEQVTIVDIDNGARLVTYAITGERGSGVIGINGA
AAHLVHPGDLVILIAYATMDDARARTYQPRIVFVDAYNKPI

3D structure

• PDB: 6p02 The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.
• Chain: R
• Resolution: 2.25 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.11: aspartate 1-decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	R	A36 E42 V68 I69 G70 I71 N72 G73 H77 H80 P81 D83 L84 V85 I86 L87 I88 A89 Y90 A91 T92 M93 D94 D95 A98 R104 I105 V106 V108 N112	A12 E18 V44 I45 G46 I47 N48 G49 H53 H56 P57 D59 L60 V61 I62 L63 I64 A65 Y66 A67 T68 M69 D70 D71 A74 R80 I81 V82 V84 N88
BS02	peptide	R	D37 L39 G41 E42 Q43 Y58 A91 T92 M93	D13 L15 G17 E18 Q19 Y34 A67 T68 M69
BS03	NMJ	R	X25 Y58 N72 G73 A74 A75	X1 Y34 N48 G49 A50 A51	MOAD: Ki=1mM
BS04	NMJ	R	R54 I88	R30 I64	MOAD: Ki=1mM

Gene Ontology

Molecular Function

• GO:0004068 aspartate 1-decarboxylase activity

Biological Process

• GO:0006523 alanine biosynthetic process

External links

• PDB: RCSB:6p02, PDBe:6p02, PDBj:6p02
• PDBsum: 6p02
• PubMed: 31953389
• UniProt: P9WIL3|PAND_MYCTU Aspartate 1-decarboxylase (Gene Name=panD)