Structure of PDB 6nbh Chain R

Receptor sequence
>6nbhR (length=379) Species: 9606 (Homo sapiens) [Search protein sequence]
VMTKEEQIFLLHRAQAQCEKRLKEVLGRPCLPEWDHILCWPLGAPGEVVA
VPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNET
REREVFDRLAMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFL
SFMLRAVSIFVKDAVLYSGATLTAAAGYAGCRVAVTFFLYFLATNYYWIL
VEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTG
CWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNATRQQYR
KLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFF
VAIIYCFCNGEVQAEIKKSWSRWTLALDF
3D structure
PDB6nbh Structure and dynamics of the active human parathyroid hormone receptor-1.
ChainR
Resolution3.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR R W361 L368 W261 L268
BS02 CLR R A386 V419 A286 V315
BS03 CLR R A279 V283 A179 V183
BS04 CLR R N358 I362 N258 I262
BS05 CLR R F291 W329 F191 W229
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004991 parathyroid hormone receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6nbh, PDBe:6nbh, PDBj:6nbh
PDBsum6nbh
PubMed30975883
UniProtQ03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

[Back to BioLiP]