Structure of PDB 6nbf Chain R

Receptor sequence
>6nbfR (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
VMTKEEQIFLLHRAQAQCEKRLKEVGRPCLPEWDHILCWPLGAPGEVVAV
PCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETR
EREVFDRLAMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLS
FMLRAVSIFVKDAVLYSAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHS
LIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGN
KKWIIQVPILASIVLNFILFINIVRVLATKLRETNTRQQYRKLLKSTLVL
MPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCN
GEVQAEIKKSWSRWTLAL
3D structure
PDB6nbf Structure and dynamics of the active human parathyroid hormone receptor-1.
ChainR
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR R A426 T427 A313 T314
BS02 CLR R W361 L368 A369 W253 L260 A261
BS03 CLR R Q438 H442 F447 Q325 H329 F334
BS04 CLR R A279 F287 A171 F179
BS05 CLR R F291 W329 F183 W221
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004991 parathyroid hormone receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6nbf, PDBe:6nbf, PDBj:6nbf
PDBsum6nbf
PubMed30975883
UniProtQ03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

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