Structure of PDB 6lpb Chain R

Receptor sequence
>6lpbR (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
IFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLV
SCPELFRIFNPDQVMGVVSRNCTEDGWSEPFPHYFDACQDYYYLSVKALY
TVGYSTSLVTLTTAMVILCCTRNFIHMNLFVSFMLRAISVFIKDWILYTV
ECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGW
GTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLF
IGIIVILVQKLQSSIYLRLARSTLLLIPLFGIHYTVFAFNVSKRERLVFE
LGLGSFQGFVVAVLYCFLNGEVQAEIKRKWR
3D structure
PDB6lpb Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.
ChainR
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R F27 N60 I83 Q146 Y150 K154 Y157 Y161 K206 Y211 V237 D298 L382 E385 L386 F2 N35 I58 Q89 Y93 K97 Y100 Y104 K143 Y148 V163 D224 L297 E300 L301
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6lpb, PDBe:6lpb, PDBj:6lpb
PDBsum6lpb
PubMed32157248
UniProtP41586|PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (Gene Name=ADCYAP1R1)

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