Structure of PDB 6gkd Chain R

Receptor sequence
>6gkdR (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
TEVVMENVTAFWEEGGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMI
MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVI
KACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLL
DSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHE
GSSYFYGTFSELQNL
3D structure
PDB6gkd Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
ChainR
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC R R516 V562 D565 Y569 M595 K598 R95 V141 D144 Y148 M174 K177
BS02 ATP R W401 T460 G461 G463 K464 T465 S466 Q493 W12 T39 G40 G42 K43 T44 S45 Q72
BS03 MG R T465 Q493 D572 T44 Q72 D151
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6gkd, PDBe:6gkd, PDBj:6gkd
PDBsum6gkd
PubMed31201318
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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