Structure of PDB 6cnb Chain R

Receptor sequence

>6cnbR (length=522) Species: 559292 (Saccharomyces cerevisiae S288C)

MPVCKNCHGTEFERDLSNANNDLVCKACGVVSEDNPIVSEVALESREATL
NNARRKLRAVSYALHIPEYITDAAFQWYKLALANNFVQGRRSQNVIASCL
YVACRKEKTHHMLIDFSSRLQVSVYSIGATFLKMVKKLHITELPLADPSL
FIQHFAEKLDLADKKIKVVKDAVKLAQRMSKDWMFEGRRPAGIAGACILL
ACRMNNLRRTHTEIVAVSHVAEETLQQRLNEFKNTKAAKLSVQKFRENDV
EDGEARPPSFVKNRKKESGIVPTLQNIVATVTLGCRLDLKTVALHARNAE
YNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII
QKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGL
IYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKMSGS
PRNLHLLPTTDTYLSKVSDDPDNLEDVDDEELNAHLLNEEASKLKERIWI
GLNADFLLEQESKRLKQEADIA

3D structure

• PDB: 6cnb Structural visualization of RNA polymerase III transcription machineries.
• Chain: R
• Resolution: 4.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	R	S75 V117 Q118 R121 S122 Y155 L162 V397 F442 K446 Q484 N485 F516 R522 L531	S45 V87 Q88 R91 S92 Y125 L132 V278 F323 K327 Q365 N366 F397 R403 L412
BS02	dna	R	A72 L73 Q118 R120 R218 R219 A251 T254 Q394 N395 R424 P517 F533 K537	A42 L43 Q88 R90 R188 R189 A221 T224 Q275 N276 R305 P398 F414 K418
BS03	ZN	R	C4 C7 C25	C4 C7 C25

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0017025 TBP-class protein binding

Biological Process

• GO:0006352 DNA-templated transcription initiation

External links

• PDB: RCSB:6cnb, PDBe:6cnb, PDBj:6cnb
• PDBsum: 6cnb
• PubMed: 30083386
• UniProt: P13393|TBP_YEAST TATA-box-binding protein (Gene Name=SPT15);
  P29056|TF3B_YEAST Transcription factor IIIB 70 kDa subunit (Gene Name=BRF1)