Structure of PDB 5z3g Chain R

Receptor sequence

>5z3gR (length=175) Species: 559292 (Saccharomyces cerevisiae S288C)

GAYKYLEELQRKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRL
GYKAKQGFVIYRVRVRRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKY
FEVILVDPQHKAIRRDARYNWICDPVHKHREARGLTATGKKSRGINKGHK
FNNTKAGRRKTWKRQNTLSLWRYRK

3D structure

• PDB: 5z3g Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate.
• Chain: R
• Resolution: 3.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	R	R12 K14 Q15 R41 R44 K47 R49 R50 A55 Q57 R68 S97 L98 R108 A111 N112 W120 Q138 K140 A141 R144 R147 W150 V155 H158 A161 R162 A166 K169 K170 S171 R172 I174 K176 G177 H178 K179 F180 N181 N182 K184 W191 K192 R193 N195 W200 Y202 R203 K204	R11 K13 Q14 R40 R43 K46 R48 R49 A54 Q56 R67 S68 L69 R79 A82 N83 W91 Q109 K111 A112 R115 R118 W121 V126 H129 A132 R133 A137 K140 K141 S142 R143 I145 K147 G148 H149 K150 F151 N152 N153 K155 W162 K163 R164 N166 W171 Y173 R174 K175
BS02	rna	R	R38 V60 Y62 N112 D136	R37 V59 Y61 N83 D107

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5z3g, PDBe:5z3g, PDBj:5z3g
• PDBsum: 5z3g
• PubMed: 29557065
• UniProt: P05748|RL15A_YEAST Large ribosomal subunit protein eL15A (Gene Name=RPL15A)