Structure of PDB 4urz Chain R

Receptor sequence
>4urzR (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
HMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQ
IKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTR
QGVEDAFYTLVREIRQH
3D structure
PDB4urz Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
ChainR
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VJP R K5 L6 D54 L56 T74 K6 L7 D55 L57 T75 MOAD: Kd=3mM
PDBbind-CN: -logKd/Ki=2.52,Kd=3.0mM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4urz, PDBe:4urz, PDBj:4urz
PDBsum4urz
PubMed25695162
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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