Structure of PDB 4o59 Chain R

Receptor sequence
>4o59R (length=332) Species: 9913 (Bos taurus) [Search protein sequence]
VKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLHYMVYMFQYDSTH
GKFNGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFT
TMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYNNTLKIVSNASCT
TNCLAPLAKVIHDHFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAA
QNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPA
KYDEIKKVVKQASEGPLKGILGYTEDQVVSCDFNSDTHSSTFDAGAGIAL
NDHFVKLISWYDNEFGYSNRVVDLMVHMASKE
3D structure
PDB4o59 High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules.
ChainR
Resolution1.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
2.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD R G7 G9 R10 I11 D32 P33 F34 T96 G97 F99 S119 C149 A180 N313 Y317 G7 G9 R10 I11 D32 P33 F34 T96 G97 F99 S119 C149 A180 N313 Y317
Gene Ontology
Molecular Function
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016740 transferase activity
GO:0035605 peptidyl-cysteine S-nitrosylase activity
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0097718 disordered domain specific binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0032481 positive regulation of type I interferon production
GO:0035606 peptidyl-cysteine S-trans-nitrosylation
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0045087 innate immune response
GO:0050821 protein stabilization
GO:0051402 neuron apoptotic process
GO:0099162 regulation of neurotransmitter loading into synaptic vesicle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0097452 GAIT complex
GO:0098850 extrinsic component of synaptic vesicle membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4o59, PDBe:4o59, PDBj:4o59
PDBsum4o59
PubMed25176140
UniProtP10096|G3P_BOVIN Glyceraldehyde-3-phosphate dehydrogenase (Gene Name=GAPDH)

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