Structure of PDB 1g0y Chain R

Receptor sequence
>1g0yR (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
CKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQAS
RIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCY
NAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNI
HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENK
PTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDP
VLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDA
AYIQLIYPVT
3D structure
PDB1g0y X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.
ChainR
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R L15 V16 P26 G75 K95 A107 Q108 A109 I110 F111 K112 K114 V124 P126 Y127 E129 F130 D162 R163 E197 V212 L10 V11 P21 G70 K90 A102 Q103 A104 I105 F106 K107 K109 V119 P121 Y122 E124 F125 D157 R158 E192 V207
Gene Ontology
Molecular Function
GO:0004908 interleukin-1 receptor activity
GO:0004909 interleukin-1, type I, activating receptor activity

View graph for
Molecular Function
External links
PDB RCSB:1g0y, PDBe:1g0y, PDBj:1g0y
PDBsum1g0y
PubMed10903327
UniProtP14778|IL1R1_HUMAN Interleukin-1 receptor type 1 (Gene Name=IL1R1)

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