Structure of PDB 8gym Chain Qc

Receptor sequence

>8gymQc (length=425) Species: 312017 (Tetrahymena thermophila SB210)

MEWNKGTYMSTSIKKIVQYFSVMTVSFHDINSLFGFFTFLTIASQLVSGT
MLAFSLVPEPMLIPMVREEEDVEDLYTDDFFWLHERGVDMLFIFSYFHLF
RKIYLNNFEYEQEAAWKSGVFTFLLFQVVVFLGLVLCCTHLSDITLAIAA
NLYDTFFAGKGKFYWWIFTSKELNTDTIIRLAYLHYVLAFFLAYLGLIHG
VDMHYDWKNESSMDGLETEMIWFDEALSNELGAMIEIILIVMIVCFFMYP
EPEALSYEFFMWGDIGFINDVRFLSVAPHWYFRPFMAWLTVCPFHKIGLF
GLIYYFFILFYQPVIHGTNEQNNYTKRNVAFVSFFINRSDIMTPKYHSVE
DNLLHQITFWLFLCSALYVTSYLPYGRFYNRINGNYGTLWSFMYIFFYLG
NSFLRRPLITELYLFNAFVKSKFLK

3D structure

• PDB: 8gym Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
• Chain: Qc
• Resolution: 2.96 Å

Enzymatic activity

• Enzyme Commision number: 1.10.2.2: Transferred entry: 7.1.1.8.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	Qc	N174 T175 D176	N174 T175 D176
BS02	U10	Qc	F54 L184 Y186	F54 L184 Y186
BS03	HEM	Qc	Q45 L46 G49 T50 L52 R67 H84 E85 V88 F126 V129 V130 G133 L134 C137 H185 Y186 A189 F190	Q45 L46 G49 T50 L52 R67 H84 E85 V88 F126 V129 V130 G133 L134 C137 H185 Y186 A189 F190
BS04	HEM	Qc	S32 G35 T38 H98 K102 W116 G119 T122 F123 H199 M203 D206 W207 K208	S32 G35 T38 H98 K102 W116 G119 T122 F123 H199 M203 D206 W207 K208
BS05	U10	Qc	Y386 G387 W390	Y386 G387 W390

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005739 mitochondrion
• GO:0016020 membrane

External links

• PDB: RCSB:8gym, PDBe:8gym, PDBj:8gym
• PDBsum: 8gym
• PubMed: 37248254
• UniProt: Q950Z1