Structure of PDB 8gym Chain QC

Receptor sequence

>8gymQC (length=426) Species: 312017 (Tetrahymena thermophila SB210)

MEWNKGTYMSTSIKKIVQYFSVMTVSFHDINSLFGFFTFLTIASQLVSGT
MLAFSLVPEPMLIPMVREEEDVEDLYTDDFFWLHERGVDMLFIFSYFHLF
RKIYLNNFEYEQEAAWKSGVFTFLLFQVVVFLGLVLCCTHLSDITLAIAA
NLYDTFFAGKGKFYWWIFTSKELNTDTIIRLAYLHYVLAFFLAYLGLIHG
VDMHYDWKNESSMDGLETEMIWFDEALSNELGAMIEIILIVMIVCFFMYP
EPEALSYEFFMWGDIGFINDVRFLSVAPHWYFRPFMAWLTVCPFHKIGLF
GLIYYFFILFYQPVIHGTNEQNNYTKRNVAFVSFFINRSDIMTPKYHSVE
DNLLHQITFWLFLCSALYVTSYLPYGRFYNRINGNYGTLWSFMYIFFYLG
NSFLRRPLITELYLFNAFVKSKFLKK

3D structure

• PDB: 8gym Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
• Chain: QC
• Resolution: 2.96 Å

Enzymatic activity

• Enzyme Commision number: 1.10.2.2: Transferred entry: 7.1.1.8.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	QC	E172 N174 T175 D176	E172 N174 T175 D176
BS02	HEM	QC	Q45 L46 G49 T50 L56 R67 H84 V88 F126 V129 V130 G133 L136 H185 Y186 A189 F190	Q45 L46 G49 T50 L56 R67 H84 V88 F126 V129 V130 G133 L136 H185 Y186 A189 F190
BS03	HEM	QC	S32 G35 T38 H98 K102 N107 W116 G119 V120 T122 F123 H199 M203 W207	S32 G35 T38 H98 K102 N107 W116 G119 V120 T122 F123 H199 M203 W207
BS04	U10	QC	Y368 Y386 G387 W390 S391	Y368 Y386 G387 W390 S391
BS05	U10	QC	F54 Y186	F54 Y186

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005739 mitochondrion
• GO:0016020 membrane

External links

• PDB: RCSB:8gym, PDBe:8gym, PDBj:8gym
• PDBsum: 8gym
• PubMed: 37248254
• UniProt: Q950Z1