Structure of PDB 9ayf Chain Q

Receptor sequence

>9ayfQ (length=780) Species: 9606 (Homo sapiens)

PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWL
QAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKID
SLNIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFK
SFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAE
ERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIK
EIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFR
EFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENISSVETPYIDYT
HLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLK
HLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYN
VYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCC
FECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPF
GIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCF
SSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKNLQFLLVFLCTFMQ
IVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAA
ICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSA
VEVIAILAASFGLLACIFFNKIYIILFKPS

3D structure

• PDB: 9ayf Promiscuous G-protein activation by the calcium-sensing receptor
• Chain: Q
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCR	Q	A168 S170 Y218 E297	A137 S139 Y187 E266
BS02	CA	Q	I81 N82 S84 L87 L88	I60 N61 S63 L66 L67
BS03	CA	Q	P39 T100 T145	P18 T79 T114
BS04	CA	Q	R66 S302	R45 S271
BS05	9IG	Q	Q681 F684 I777 W818 Y825	Q619 F622 I692 W733 Y740
BS06	AV0	Q	K805 F809 A850 C851 F854 Y858	K720 F724 A765 C766 F769 Y773

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:9ayf, PDBe:9ayf, PDBj:9ayf
• PDBsum: 9ayf
• PubMed: 38632411
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)