Structure of PDB 9axf Chain Q

Receptor sequence

>9axfQ (length=791) Species: 9606 (Homo sapiens)

YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYAS
SSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYG
RPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVV
FSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIG
FALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDEN
ISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCA
DIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPED
GSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGT
RKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNREL
SYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTN
LQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMA
LGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFI
PAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFK

3D structure

• PDB: 9axf Promiscuous G-protein activation by the calcium-sensing receptor
• Chain: Q
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCR	Q	S147 A168 S170 Y218 E297 A298	S128 A149 S151 Y199 E278 A279
BS02	CA	Q	I81 N82 S84 L87 L88	I62 N63 S65 L68 L69
BS03	CA	Q	P39 T100 T145	P20 T81 T126
BS04	CA	Q	F42 S302 L304	F23 S283 L285
BS05	9IG	Q	Q681 F684 I777 W818 F821 Y825 E837	Q631 F634 I705 W746 F749 Y753 E765
BS06	Y01	Q	F619 F806 F809 A850	F569 F734 F737 A778
BS07	CLR	Q	F788 F815 I819	F716 F743 I747
BS08	CLR	Q	G774 I777	G702 I705

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:9axf, PDBe:9axf, PDBj:9axf
• PDBsum: 9axf
• PubMed: 38632411
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)