Structure of PDB 9avl Chain Q

Receptor sequence

>9avlQ (length=803) Species: 9606 (Homo sapiens)

PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWL
QAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKID
SLNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNK
NQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFR
EEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLE
PLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQI
PGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLPLCTGDENISSVETPYI
DYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQ
VLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVG
YYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEP
TCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWT
EPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLL
CCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAK
INLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSL
MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWIS
FIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIE
EVR

3D structure

• PDB: 9avl Promiscuous G-protein activation by the calcium-sensing receptor
• Chain: Q
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCR	Q	T145 S147 A168 S170 Y218 E297	T118 S120 A141 S143 Y191 E270
BS02	CA	Q	T100 T145	T79 T118
BS03	9IG	Q	Q681 F684 W818 Y825 E837	Q622 F625 W748 Y755 E767
BS04	Y01	Q	F806 F854 N855	F736 F784 N785
BS05	A1AF7	Q	F809 I813 A850	F739 I743 A780

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:9avl, PDBe:9avl, PDBj:9avl
• PDBsum: 9avl
• PubMed: 38632411
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)