Structure of PDB 9asb Chain Q

Receptor sequence

>9asbQ (length=804) Species: 9606 (Homo sapiens)

GPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRW
LQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKN
QFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFRE
EAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEP
LIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIP
GFREFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENISSVETPYI
DYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQ
VLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVG
YYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEP
TCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWT
EPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLL
CCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAW
GLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGS
LMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWI
SFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTI
EEVR

3D structure

• PDB: 9asb Promiscuous G-protein activation by the calcium-sensing receptor
• Chain: Q
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCR	Q	R66 W70 S147 A168 S170 Y218 E297 A298	R46 W50 S119 A140 S142 Y190 E269 A270
BS02	CA	Q	P39 T100 N102 T145	P19 T80 N82 T117
BS03	CA	Q	F42 S302	F22 S274
BS04	9IG	Q	Q681 F684 E767 L773 I777 T780 W818 F821 Y825 E837	Q622 F625 E698 L704 I708 T711 W749 F752 Y756 E768
BS05	Y01	Q	F806 F846 F854 N855	F737 F777 F785 N786
BS06	A1AF7	Q	F619 K805 F809 I813 I839 A843	F560 K736 F740 I744 I770 A774

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:9asb, PDBe:9asb, PDBj:9asb
• PDBsum: 9asb
• PubMed: 38632411
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)