Structure of PDB 8ir1 Chain Q

Receptor sequence

>8ir1Q (length=203) Species: 9606 (Homo sapiens)

VLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPI
VRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTE
SLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVR
NVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVE
KKK

3D structure

• PDB: 8ir1 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
• Chain: Q
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Q	L10 H13 K16 W18 R20 W25 Q28 R31 K32 R35 R36 R39 K42 R44 R56 V59 R60 P62 T63 Y66 H67 R71 G73 R74 R92 R101 R102 R103 S106 R129 V157 R158 N159 K165 R183 M184 R186 A187 R190 K197 R198	L2 H5 K8 W10 R12 W17 Q20 R23 K24 R27 R28 R31 K34 R36 R48 V51 R52 P54 T55 Y58 H59 R63 G65 R66 R84 R93 R94 R95 S98 R121 V149 R150 N151 K157 R175 M176 R178 A179 R182 K189 R190
BS02	rna	Q	F26 N27 A30 R34	F18 N19 A22 R26

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0001824 blastocyst development
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0060348 bone development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ir1, PDBe:8ir1, PDBj:8ir1
• PDBsum: 8ir1
• PubMed: 37491604
• UniProt: P26373|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)