Structure of PDB 8ie3 Chain Q

Receptor sequence

>8ie3Q (length=210) Species: 9606 (Homo sapiens)

APSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPA
SGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPR
RRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLT
GPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKE
AAEQDVEKKK

3D structure

• PDB: 8ie3 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
• Chain: Q
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Q	F26 N27 A30 R34	F25 N26 A29 R33
BS02	rna	Q	A2 S4 L10 K11 H13 H15 K16 W18 W25 Q28 P29 R31 K32 R35 R36 R39 R44 R56 V59 R60 P62 T63 Y66 H67 R71 G73 R74 L78 R92 D99 R101 R102 R103 R129 K135 R158 N159 K163 R183 M184 R186 N188 K197 R198	A1 S3 L9 K10 H12 H14 K15 W17 W24 Q27 P28 R30 K31 R34 R35 R38 R43 R55 V58 R59 P61 T62 Y65 H66 R70 G72 R73 L77 R91 D98 R100 R101 R102 R128 K134 R157 N158 K162 R182 M183 R185 N187 K196 R197

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0001824 blastocyst development
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0060348 bone development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ie3, PDBe:8ie3, PDBj:8ie3
• PDBsum: 8ie3
• PubMed: 37491604
• UniProt: P26373|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)