Structure of PDB 8g8n Chain Q

Receptor sequence

>8g8nQ (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]

EIVLTQSPDFQSVTPKEKVTITCSAALSYMYWYQQKPDQSPKLWVHGTSN
LASGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCHHWSNTQWTFGGGTK
VEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA
LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS
PVTKSFNRGEC

3D structure

PDB

8g8n XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.

Chain

Resolution

3.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	Q	W91 W96	W88 W93

External links

PDB	RCSB:8g8n, PDBe:8g8n, PDBj:8g8n
PDBsum	8g8n
PubMed	38164757

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