Structure of PDB 7qwr Chain Q

Receptor sequence

>7qwrQ (length=187) Species: 9986 (Oryctolagus cuniculus)

GVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRL
FMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVC
ALRVSSRARSRILKAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRH
FGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN

3D structure

• PDB: 7qwr Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
• Chain: Q
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Q	G2 H7 N8 D10 R11 K12 V13 R14 R15 S20 F34 R37 R38 T42 F43 K49 R50 M53 S54 R55 T56 N57 S62 S64 R65 R68 K69 L72 P73 R75 K78 T85 T87 D88 D89 V90 R91 R104 S106 S107 R108 C134 G135 T136 L138 L139 S140 P142 R143 K144 G145 R146 E147 V148 R150 F152 T158 P159 H160 H162 K164 Y166 R168 S169 K173 R176 R178 R181 S183 R184 G185 Y186 K187 N188	G1 H6 N7 D9 R10 K11 V12 R13 R14 S19 F33 R36 R37 T41 F42 K48 R49 M52 S53 R54 T55 N56 S61 S63 R64 R67 K68 L71 P72 R74 K77 T84 T86 D87 D88 V89 R90 R103 S105 S106 R107 C133 G134 T135 L137 L138 S139 P141 R142 K143 G144 R145 E146 V147 R149 F151 T157 P158 H159 H161 K163 Y165 R167 S168 K172 R175 R177 R180 S182 R183 G184 Y185 K186 N187

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005791 rough endoplasmic reticulum
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qwr, PDBe:7qwr, PDBj:7qwr
• PDBsum: 7qwr
• PubMed: 35201867
• UniProt: G1TX70