Structure of PDB 7qp6 Chain Q

Receptor sequence

>7qp6Q (length=99) Species: 9606 (Homo sapiens) [Search protein sequence]

TKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNIVEAAAVR
DISEASVFDAYVLPKLYVKLHYCVSCAIHSKVVRNRSREARKDRTPPPR

3D structure

PDB

7qp6 Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.

Chain

Resolution

4.7 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Q	T2 K3 K4 R5 R6 N7 N8 G9 R10 K13 G14 R15 G16 H17 R28 K32 K34 K37 F39 I41 V75 S76 I79 V83 R85 N86 R87 S88 R92 R95 P98 R100	T1 K2 K3 R4 R5 N6 N7 G8 R9 K12 G13 R14 G15 H16 R27 K31 K33 K36 F38 I40 V74 S75 I78 V82 R84 N85 R86 S87 R91 R94 P97 R99
BS02	ZN	Q	C26 C74 C77	C25 C73 C76

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045296	cadherin binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0033119	negative regulation of RNA splicing

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:0098556	cytoplasmic side of rough endoplasmic reticulum membrane
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7qp6, PDBe:7qp6, PDBj:7qp6
PDBsum	7qp6
PubMed	35489072
UniProt	P62854\|RS26_HUMAN Small ribosomal subunit protein eS26 (Gene Name=RPS26)