Structure of PDB 7pmn Chain Q

Receptor sequence
>7pmnQ (length=766) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLLI
EKSSASLPNQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQR
AIMDLGASVGFEMKDLSMGFSMDIGYLLHFPEFFSLFKSWGDTITILVIN
ASSLGQIYKQMFEKKKGKIETYSYLVDINFEFVYFKLYRRLSQETTKLKE
ERGLQFLLLLQSPFITKLLGTIRLLNQMPIVKLSTLLKKLVNHVLSSGSW
ISHLIKLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPL
PDHGGIQNDFDLNTSWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTIL
TSAEFVHDAFSNDALNVLRGMLKEWWDEALKENSTADLLVNSLASWVQNP
NAKLFDGLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKY
SPENCYAYSQYMMKAVRTNPMFSYLDLNIKRYWDLLIWMDKFNFSGLACT
AVSQWQLKKFLSPIYQPEFEDWMMIILDSMLKTKQSYLKLNNSLNGFSHL
FSKPLMKRVKKLFKNQQEFILDPQYEADYVIPVLPGSHLNVKNPLLELVK
SLCHVMLLSKSTILEIRTLRKELLKIFELREFAKVAEFKDPSLSLVVPDF
LCEYCFFISDIDFCKAAPESIFSCVRCHKAFNQVLLQEHLIQKLRSDIES
YLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLPRESIVQKLNVFKQVAK
YYGFDILLSCIADLTI
3D structure
PDB7pmn A conserved mechanism for regulating replisome disassembly in eukaryotes.
ChainQ
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN Q C2108 C2130 C2133 C652 C674 C677
BS02 ZN Q C2164 C2167 C2179 C2181 C708 C711 C723 C725
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003729 mRNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0032183 SUMO binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0007064 mitotic sister chromatid cohesion
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0035822 gene conversion
GO:0042276 error-prone translesion synthesis
GO:0045004 DNA replication proofreading
Cellular Component
GO:0005634 nucleus
GO:0005657 replication fork
GO:0008622 epsilon DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle
GO:0043596 nuclear replication fork

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pmn, PDBe:7pmn, PDBj:7pmn
PDBsum7pmn
PubMed34700328
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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