Structure of PDB 7c5q Chain Q

Receptor sequence

>7c5qQ (length=333) Species: 469008 (Escherichia coli BL21(DE3))

MSKVGINGFGRIGRLVLRRLLEVKSNIDVVAINDLTSPKILAYLLKHDSN
YGPFPWSVDFTEDSLIVDGKSIAVYAEKEAKNIPWKAKGAEIIVECTGFY
TSAEKSQAHLDAGAKKVLISAPAGEMKTIVYNVNDDTLDGNDTIVSVASC
TTNCLAPMAKALHDSFGIEVGTMTTIAAYTGTQSLVDGPRGKDLRASRAA
AENIIPHTTGAAKAIGLVIPELSGKLKGHAQRVPVKTGSVTELVSILGKK
VTAEEVNNALKQATTNNESFGYTDEEIVSSDIIGSHFGSVFDATQTEITA
VGDLQLVKTVAWYDNEYGFVTQLIRTLEKFAKL

3D structure

• PDB: 7c5q Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
• Chain: Q
• Resolution: 2.13 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	Q	G8 G10 R11 I12 D34 L35 K78 C96 T97 F99 S120 C150 N315 F319	G8 G10 R11 I12 D34 L35 K78 C96 T97 F99 S120 C150 N315 F319
BS02	G3H	Q	T180 G181 T182	T180 G181 T182
BS03	PO4	Q	H163 G167 I168 K225	H163 G167 I168 K225

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7c5q, PDBe:7c5q, PDBj:7c5q
• PDBsum: 7c5q
• PubMed: 34827563
• UniProt: A0A140NCK4