Structure of PDB 7alb Chain Q

Receptor sequence
>7albQ (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
PRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTK
GYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYL
PNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVE
ATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIR
3D structure
PDB7alb A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
ChainQ
Resolution1.979 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.16: GTP cyclohydrolase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN Q C141 H144 C212 C84 H87 C155
BS02 QBQ Q G164 L165 S166 K167 R170 G107 L108 S109 K110 R113
BS03 QBQ Q C141 H143 H144 V181 E183 R216 C84 H86 H87 V124 E126 R159
Gene Ontology
Molecular Function
GO:0003934 GTP cyclohydrolase I activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7alb, PDBe:7alb, PDBj:7alb
PDBsum7alb
PubMed33229582
UniProtP30793|GCH1_HUMAN GTP cyclohydrolase 1 (Gene Name=GCH1)

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