Structure of PDB 6ow7 Chain Q

Receptor sequence
>6ow7Q (length=191) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
SAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQ
FLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNAYDLEAIMYN
PKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRI
KLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLIL
3D structure
PDB6ow7 Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.
ChainQ
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G72 Q77 C130 L131 H173 E174 H177
Catalytic site (residue number reindexed from 1) G71 Q76 C119 L120 H162 E163 H166
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N9Y Q R68 G69 G70 V71 G72 Q77 G129 C130 L131 H173 E174 H177 R67 G68 G69 V70 G71 Q76 G118 C119 L120 H162 E163 H166 MOAD: ic50=1nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0043686 co-translational protein modification

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Molecular Function
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Biological Process
External links
PDB RCSB:6ow7, PDBe:6ow7, PDBj:6ow7
PDBsum6ow7
PubMed31160176
UniProtQ8DP79|DEF_STRR6 Peptide deformylase (Gene Name=def)

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