Structure of PDB 6d5w Chain Q

Receptor sequence
>6d5wQ (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEASAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQ
IKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTR
QGVEDAFYTLVREIRQH
3D structure
PDB6d5w Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
ChainQ
Resolution2.478 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG Q S17 T35 S18 T36
BS02 GNP Q G13 G15 K16 S17 A18 F28 V29 D30 P34 T35 G60 N116 K117 D119 S145 A146 G14 G16 K17 S18 A19 F29 V30 D31 P35 T36 G61 N117 K118 D120 S146 A147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6d5w, PDBe:6d5w, PDBj:6d5w
PDBsum6d5w
PubMed30205005
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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