Structure of PDB 5epi Chain Q

Receptor sequence

>5epiQ (length=703) Species: 1601067 (Influenza B virus (B/Memphis/13/2003))

SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYTARPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLAD
LFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNE
SSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDIDFKLGQTISRLRD
ISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTWEDLR
PIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLEKY
STLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKTNYAK
WATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNLLSTL
TSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHT
SLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDV
VTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTN
KIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRVNSPK
TFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLL
LIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGFEKEG
SKV

3D structure

• PDB: 5epi Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
• Chain: Q
• Resolution: 4.1 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Q	T366 G367 G369 L370 T371 Y372 H506 V513 T515 R558 V559 N560 G561 T562	T353 G354 G356 L357 T358 Y359 H493 V500 T502 R545 V546 N547 G548 T549

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:5epi, PDBe:5epi, PDBj:5epi
• PDBsum: 5epi
• PubMed: 26711008
• UniProt: Q5V8Z9