Structure of PDB 4fxy Chain Q

Receptor sequence
>4fxyQ (length=664) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SSYTAAGRNVLRWDLSPEQIKTRTEQLIAQTKQVYDTVGTIALKEVTYEN
CLQVLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKKLSRFDIEMS
MREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLSEAIRNE
IKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDED
KYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPLR
AQVAKLLGYNTHADFVLELNTAKSTSRVAAFLDDLSQKLKPLGEAEREFI
LSLKKKECEERGFEYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPIE
VVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFYL
DLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPVAGRPSLL
RHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVW
DVDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQS
LHTNATLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYL
WSEVFSMDMFHSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFLQ
REPNQKAFLMSRGL
3D structure
PDB4fxy Allosteric inhibition of the neuropeptidase neurolysin.
ChainQ
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H474 E475 H478
Catalytic site (residue number reindexed from 1) H460 E461 H464
Enzyme Commision number 3.4.24.16: neurolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0W2 Q Y49 I72 E73 Y76 R80 D110 S114 S146 R491 Y35 I58 E59 Y62 R66 D96 S100 S132 R477
BS02 ZN Q H474 H478 E503 H460 H464 E489
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0006111 regulation of gluconeogenesis
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0030163 protein catabolic process
GO:0043171 peptide catabolic process
GO:1902809 regulation of skeletal muscle fiber differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fxy, PDBe:4fxy, PDBj:4fxy
PDBsum4fxy
PubMed25378390
UniProtP42676|NEUL_RAT Neurolysin, mitochondrial (Gene Name=Nln)

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