Structure of PDB 1nvx Chain Q

Receptor sequence
>1nvxQ (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTGGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB1nvx Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
ChainQ
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG Q S17 T35 S17 T35
BS02 GTP Q G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 T35 G60 N116 K117 D119 S145 K147 G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 T35 G60 N116 K117 D119 S145 K147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:1nvx, PDBe:1nvx, PDBj:1nvx
PDBsum1nvx
PubMed12628188
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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