Structure of PDB 8aox Chain PA

Receptor sequence
>8aoxPA (length=432) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
PVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDHANARAFSHLAIKLIE
QEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLAS
AAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQD
VYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWADE
QVLKAKNIGLCSTDLTEGRRGKLSIMRGKKLEPCDRVLFSVGSTLYPESR
KLLKSWHLPSVFHLKGKLSTCRCDTVVSCEGYVVKRITMSPGLYGKTTGY
AVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVTPE
DAQKLLVGLNQNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVRERTL
TCCCLWAFKKQKTHTVYKRPDTQSIQKVQAEF
3D structure
PDB8aox Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores.
ChainPA
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN PA H79 E129 C134 C141 H77 E127 C132 C139
BS02 SAM PA G65 P83 S86 D89 R92 T137 D138 Q151 D152 G63 P81 S84 D87 R90 T135 D136 Q149 D150
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008174 mRNA methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0016556 mRNA modification

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8aox, PDBe:8aox, PDBj:8aox
PDBsum8aox
PubMed36913573
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

[Back to BioLiP]